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1. Tang, X., Xue, D., Zhang, T., Nilsson-Payant, B.E., Carrau L., Duan, X., Gordillo, M., Tan, A.Y., Xiang, J.,   Schwartz, R.E.*, tenOever, B.R.*, Evans, T.*, Chen, S.*, ”A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection”, Nature Cell Biology, accepted.

 

2. Han, Y., Tan, L., Zhou, T., Yang, L., Carrau, L., Lacko L.A., Saeed, M., Zhu, J., Zhao, Z., Nilsson-Payant, B.E., Lira Neto, F.T., Cahir, C., Giani, A.M., Chai, J., Li, Y., Dong, X., Moroziewicz, D., The NYSCF Global Stem Cell Array® Team, Paull, D., Zhang, T., Koo, S., Tan, C., Danziger1, R., Ba, Q., Feng, L., Chen, Z., Zhong, A., Wise, G.J., Xiang, J.Z., Wang, H., Schwartz, R.E., tenOever, B.R., Noggle, S.A., Rice, C.M., Qi, Q.,  Evans, T., Chen, S.*, “A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants”, Cell Stem Cell, 29, 1475 (2022), PMID: 36206731.

 

3. Han, Y., Yang, L., Lacko, L.A., Chen, S.*, “Human organoid models to study SARS-CoV-2 infection”, Nature Methods, 19, 418 (2022), PMID: 35396481.

 

4. Vandana, J.J., Lacko, L.A., Chen, S.*, “Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis”, Cell Stem Cell, 29, 873 (2022), PMID: 35659872.

 

5. Argueta, L.B., Lacko, L.A., Bram, Y., Tada, T., Carrau, L., Rendeiro, A.F., Zhang, T., Uhl, S., Lubor, B.C., Chandar, V., Gil, C., Zhang, W., Dodson, B.J., Bastiaans, J., Prabhu, M., Houghton, S., Redmond, D., Salvatore, C.M., Yang, Y.J., Elemento, O., Baergen, R.N., tenOever, B.R., Landau, N.R., Chen, S.* Schwartz, R.E.*, Stuhlamann, H.*, “Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy”, iScience, 25, 5 (2022), PMID: 35434541.

 

6. Yaron, T.M., Heaton, B.E., Levy, T.M., Johnson, J.L., Jordan, T.X., Cohen, B.M., Kerelsky, A., Liu, T., Liberatore, K.M., Bulaon, D.K., Nest, S.J.V., Koundouros, N., Kastenhuber, K.R., Mercadante, M.N., Shobana-Ganesh, K., He, L., Schwartz, R.E., Chen, S., Weinstein, H., Elemento, O., Piskounova, E., Nilsson-Payant., B.E., Lee, G., Trimarco, J.D., Burke, K.N., Hamele, C.E., Chaparian, R.P., Harding, A.T., Tata, A., Zhu, X., Tata, P.R., Smith, C.M., Possemato, A.P., Tkachev, S.L., Hornbeck, P.V., Heesom, K., Kavanagh-Williamson, M., Matthews, D.A., tenOever, B.R., Cantley, L.C., Blenis, J., Heaton, N.S., Science Signaling, 15, 757 (2022), PMID: 36282911.

 

7. Tee, S.S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R.M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E.R., Chen, S., Sigel, C., Low, S.W., Jarnagin, W.R., Thompson, C.B., Schietinger, A., Keshari, K.R., “Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging”, Science Advance, 8, 14 (2022), PMID: 35385296.

 

8. Ghazizadeh, Z., Zhu, J., Fattahi, F., Tang, A., Sun, X., Amin, S., Tsai, S.Y., Khalaj, M., Zhou, T., Samuel, R.M., Zhang, T., Ortega, F.A., Gordillo, M., Moroziewicz, D., NYSCF Global Stem Cell Array® Team, Paull, D., Noggle, S.A., Xiang, J.Z., Studer, L., Christini, D.J., Pitt, G.S., Evans, T., Chen, S.*, “A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for the derivation of human SAN-like cells”, iScience, 25, 104153 (2022), PMID: 35434558.

 

9. Lan, Y., Banks, K.M., Pan, H., Verma, N., Dixon, G.R., Zhou, T., Ding, B., Elemento, O., Chen, S., Huangfu, D., Evans, T., “Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation”, Cell Reports, 37, 110095, PMID: 34879277.

 

10. Han, Y., Zhu, J., Yang, L., Nilsson-Payant, B.E., Hurtado, R., Lacko, L.A., Sun, X., Gade, A.R., Higgins, C.A., Sisso, W.J., Dong, X., Wang, M., Chen, Z., Ho, D.D., Pitt, G.S., Schwartz, R.E.*, tenOever, B.R.*, Evans, T.*, Chen, S.*, “SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells”, “Circulation Research, 130, 963 (2022), PMID: 35255712.

 

11. Lan, Y., Banks, K.M., Pan, H., Verma, N., Dixon, G.R., Zhou, T., Ding, B., Elemento, O., Chen, S., Huangfu, D., Evans, T., “Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation”, Cell Rep. 37, 110095 (2021), PMID: 34879277.

 

12. Upadhya, S., Rehman, J. *, Malik, A.B. *, Chen, S.*, “Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection”, Physiology, (2021) PMID: 34698589.

 

13. Duan, X., Tang, X., Nair, M.S., Zhang, T., Qiu, Y., Zhang, W., Wang, P., Huang, Y., Xiang, J., Wang, H., Schwartz, R.E. *, Ho, D.D. *, Evans, T. *, Chen, S.*, “An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection”, Cell Rep., 37, 109920 (2021), PMID: 34731648.

 

14. Duan, X., Wang, H., Ho, D.D., Schwartz, R.E., Evans, T., Chen, S.*, “Comments on 'An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection'”. J Mol Cell Biol., (2021), PMID: 34850919.

 

15. Duarte, R.R.R., Copertino, D.C., Jr., Iñiguez, L.P., Marston, J.L., Bram, Y., Han, Y., Schwartz, R.E., Chen, S., Nixon, D.F., Powell, T.R., “Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry”, Mol Med., 27,105, (2021), PMID: 34503440.

 

16. Tang, X., Uhl, S., Zhang, T., Xue, D., Li, B., Vandana, J.J., Acklin, J.A., Bonnycastle, L.L., Narisu, N., Erdos, M.R., Bram, Y., Lacko, L.A., Min, Z., Lim, J.K.,  Borczuk, A., Xiang, J., Naji, A., Collins, F.S., Evans, T., Liu, C.,*, tenOever, B.R. *, Schwartz, R.E.,*, Chen, S.*, “SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation”, Cell Metabolism, 21, S1550 (2021), PMID: 34081913.

 

17. Yang., L, Han, Y., Jaffré, F., Nilsson-Payant, B.N., Bram, Y., Wang, P., Zhu, J., Zhang,T., Redmond, D., Houghton, S., Uhl, S., Borczuk, A., Huang, Y., Richardson, C., Chandar, V., Acklin, J.A., Lim, J.K., Xiang, J., Ho, D.H. *, tenOever, B.R. *, Schwartz, R.E.,*, Evans, T.,*, Chen, S.*, “An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts”, Circ. Res., 129, 33 (2021), PMID:33853355.

 

18. Yang., L, Nilsson-Payant, B.N., Han, Y., Jaffré, F., Zhu, J., Wang, P., Zhang,T., Redmond, D., Houghton, S., Møller, R., Carrau, L., Horiuchi, S., Goff, M., Lim, J.K., Bram, Y., Richardson, C., Chandar, V., Borczuk, A., Huang, Y., Xiang, J., Ho, D.H. *, Schwartz, R.E.,*, tenOever, B.R. *, Evans, T.,*, Chen, S.*, “Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2”, Stem Cell Reports, 16, 2274 (2021), PMID: 34403650.

 

19. Han, Y., Duan, X., Yang, L., Nilsson-Payant, B.E., Wang, P., Duan, F., Tang, X., Yaron, T.M., Zhang, T., Uhl, S., Bram Y., Richardson, C., Zhu, J., Zhao, Z., Redmond. D., Houghton, S., Nguyen, D.T., Xu, D., Wang, X., Jessurun, J., Borczuk, A., Huang, Y., Johnson, J.L., Liu, Y., Xiang, J., Wang, H. *, Cantley, L.C.*, tenOever, B.R.*, Ho, D.D.*, Pan, F*, Evans, T*, Chen, H.J.*, Schwartz, R.E.*, Chen, S.*, “Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids”, Nature, 589, 270 (2020), PMID: 33116299.

 

20. Yang, L., Han, Y., Nilsson-Payant, B.E., Gupta, V., Wang, P., Duan, X., Tang, X., Zhao, Z., Jaffré, F., Zhang, Tuo., Kim T.W., Harschnitz, O., Redmond. D., Houghton, S., Liu, C., Naji, A., Ciceri, G., Guttikonda, S., Bram, Y., Nguyen, D.T., Gioffi, M., Chandar, V., Hoagland, D.A., Huang, Y., Xiang, J., Wang, H., Lyden, D., Borczuk, A., Chen, H.J., Studer, L., Pan, F.C. *, Ho, D.D. *, tenOever, B.R. *, Evans, T. *, Schwartz, R.E. *, Chen, S.*, “A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids”, Cell Stem Cell, 27, 125 (2020), PMID: 32579880.

 

21. Cederquist, G.Y., Tchieu, J., Callahan, S.J., Ramnarine, K., Ryan, S., Zhang, C., Rittenhouse, C., Zeltner, N., Chung, S.Y., Zhou, T., Chen, S., Betel, D., White, R.M., Tomishima, M., Studer, L., “A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes”, Cell Stem Cell,  27, 35 (2019), PMID: 32619517.

 

22. Cook, B., Walker, N., Zhang, Q., Chen, S.*, Evans T*, “The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3-beta signaling”, J Biol Chem., 296, 1006962021, (2021), PMID: 33895139.

 

23. Li, Q.V., Dixon, G., Verma, N., Rosen, B.P., Gordillo, M., Luo, R., Xu, C., Wang, Q., Soh, C., Yang, D., Crespo, M., Shukla, A., Xiang, Q., Dündar, F., Zumbo, P., Witkin, M., Koche, R., Betel, D., Chen, S., Massagué, J., Garippa, R., Evans, T., Beer, M.A., Huangfu, D., “Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation”, Nat. Genet., 51, 999 (2019), PMID: 31110351.

 

24. Vandana, J.J., Lacko, L.A., Chen, S. *, “High Throughput Phenotypic Screens in Stem Cell Biology”, Cell Chem. Biol., 28(3):257-70, PMID: 33651977.

 

25. Giani, A.M., Chen, S. *, “Human Pluripotent Stem Cell-based Organoids and Cell Platforms for Modelling SARS-CoV-2 Infection and Drug Discovery”, Stem Cell Res., 53:102207, PMID: 33677394.

 

26. Sleiman, Y., Souidi, M., Kumar, R., Yang, E., Jaffré, F., Zhou, T., Bernardin, A., Reiken, S., Cazorla, O., Kajava, A.V., Moreau, A., Pasquié, J.L., Marks, A.R., Lerman, B.B., Chen, S., Cheung, J.W., Evans, T., Lacampagne, A., Meli, A.C., “Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes”, EBioMedicine., 60,103024, (2020), PMID: 32980690.

 

27. Tsai, S.Y., Ghazizadeh, Z., Wang, H.J., Amin, S., Ortega, F.A., Badieyan, Z.S., Hsu, Z.T., Gordillo, M., Kumar, R., Christini, D.J., Evans, T. *, Chen, S.*, “A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity”, Cardiovas. Res., 116, 658 (2020), PMID: 31173076.

 

28. Pan, F.C. *, Evans, T. *, Chen, S.*, “Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids.” J. Mol. Cell Biol., 12, 580 (2020). PMID: 32652003.

 

29. Zhang, M., Vandana, J.J., Lacko, L.A., Chen, S. *, “Modeling cancer progression using human pluripotent stem cell-derived cells and organoids”, Stem Cell Res., 49:102063, (2020), PMID: 33137568.

 

30. Lacko, L.A., Chen, S. *, “Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics”, J. Mol. Cell Biol., 12(8):666-7, (2020), PMID: 31638141.

 

31. Tan, L., Lacko, L.A., Zhou, T., Tomoiaga, D., Hurtado, R., Zhang, T., Sevilla, A., Mason, C., Noggle, S., Evans, T., Stuhlmann, H.*, Schwartz, R.E.*, Chen, S.*, “Pre- and Peri-implantation Zika Virus Infection Impairs Fetal Development by Targeting Trophectoderm Cells”, Nat Commun, 10, 4155 (2019), PMID: 31519912.

 

32. Cook, B., Rafiq, R., El-Debs, M., Chiaravalli, J., Glickman, J.F., Chen. S.*, and Evans, T.,*, “”, 31031140.

 

33. Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., Stanley, V., Guemez-Gamboa, A., Evans, T., Chen. S., Tan, L., Molina, H., Sheets, N., Shiryaev S.A., Terskikh A.V., Gladfelter, A.S., Shresta, S., Xu, Z., Gleeson, J.G., “Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors”, Neuron, 101:1, (2019), PMID: 30713029

 

34. Zhou, T., Kim, T.W., Chong, C.N., Tan, L., Amin, S., Mukherjee, S., Ghazizadeh, Z., Zeng, H., Guo, M., Crespo, M., Zhang, T., Kenyon, R., Robinson, C.L., Apostolou, E., Wang, H., Xiang, J.Z., Evans, T., Studer, L., Chen. S.*, “A Pluripotent Stem Cell-based Platform to Discover Gene-Environment Interactions that Impact Human Pancreatic β -Cell and Dopamine Neuron Survival”, Nat Commun, 9:4815, (2018), PMID: 30446643.

 

35. Amin, S., Cook, B., Zhou, T., Ghazizadeh, Z., Lis, R., Zhang, T., Khalaj, M., Crespo, M., Perera, M., Xiang, J.Z., Zhu, Z., Tomishima, T., Liu, C., Naji, A., Evans, T., Huangfu, D. *, Chen. S.*, “Discovery of a Drug Candidate for GLIS3-Associated Diabetes”, Nat Commun, 9, 2681, (2018), PMID: 29992946.

 

36. Robinson, C.L., Chong, A.C., Ashbrook, A.W., Jeng, G., Jin, J., Chen, H., Tang, E.I., Martin, L.A., Kim, R.S., Kenyon, R.M., Do, E., Luna, J.M., Saeed, M., Zeltser, L., Ralph, H., Dudley, V.L., Goldstein, M., Rice, C.M., Cheng, C.Y.*, Seandel, M.*, Chen. S.*, “Male Germ Cells Support Long-Term Propagation of Zika Virus”, Nat Commun, 9:2090, (2018), PMID: 29844387.

 

37. Mukherjee, S., Zhang, T., Lacko, L.A., Xiang, J.Z., Bulter, J.M., Chen. S.*, “Derivation and characterization of a UCP1 reporter human ES cell line”, Stem Cell Research, 30:12-21. 2018. PMID: 29777802. 

 

38. Crespo, M., Vilar, E., Tsai, S., Chang, K., Amin, S., Srinivasan, T., Zhang, T., Pipalia, N.H., Chen, H.J., Witherspoon, M., Gordillo, M., Xiang, J.Z., Maxfield, F.R., Lipkin, S., Evans, T.*, Chen. S.*, “Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing”, Nat. Med., 23(7):878-884. PMID: 28628110. (Cover story, highlighted by Nat Rev Mol Cell Bio)

 

39. Zhou, T., Tan, L., Cederquist, Y. C., Fan, Y., Hartley, B.J., Mukherjee, S., Tomishima, M., Brennand, K.J., Zhang. Q., Schwartz, R.E., Evans T., Studer, L.*, and Chen, S.*, “High Content Screening in hESC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain”, Cell Stem Cell, 21(2):274-283.e5, PMID: 28736217.

 

40. Shi, Z.D., Lee, K., Yang, D., Amin, S., Verma, N., Li, Q.V., Zhu, Z., Soh, C.L., Kumar, R., Evans, T., Chen. S.*, Huangfu, D.*, “hPSC modeling of GATA6 haploinsufficiency in human pancreatic development”, Cell Stem Cell, 20(5):675-688 (2017), PMID: 2819660.

 

41. Guo, M., Zhang, T., Dong, X., Xiang, J.Z., Lei, M., Evans, T., Graumann, J., Chen. S.*, “Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E”, Cell Reports, 19(8):1512 (2017), PMID: 28538172.

 

42. Ghazizadeh, Z., Kao, D., Amin, S., Cook, B., Rao, S., Zhang, T., Xiang, J.Z., Kenyon, R., Kaymakcalan, O., Liu, C., Evans T., Chen. S.*, “ROCKII Inhibition Promotes the Maturation of Human Pancreatic Beta-like Cells”, Nat Commun, 8 (1): 298 (2017), PMID: 28824164.

 

43. Tchieu, J., Zimmer, B., Fattahi, F., Amin, S., Zeltner, N., Chen, S., Studer, L., “A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages”, Cell Stem Cell, 21(3):399-410.e7, (2017), PMID: 28886367.

 

44. Zeng, H., Guo, M., Zhou, T., Tan, Lei., Chong, C., Zhang, T., Dong, X., Xiang, J. X., Yu, A.S., Yue, L., Qi, Q, Evans, T., Graumann, J., Chen. S.*, “An Isogenic Human ESC Platform for Functional Evaluation of GWAS Identified Diabetes Genes and Drug Discovery”, Cell Stem Cell, 19: 324 (2016), PMID: 27524441.

 

45. Chen, H.J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D.J., Serda, R., Mackeyev, Y., Curley, S.A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., Huang, E., Shen, X., Lipkin, S.M., Copeland, N.G., Jenkins, N.A., Shuler, L. “A recellularized human colon model identifies cancer driver genes.” Nat Biotechnol. (8):845-51, PMID: 27398792.

 

46. Tsai, S., Chen, S., Evans T., “Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling”, Current Protocols in Stem Cell Biology, 40:1F.16.1, PMID: 28152183

 

47. Li, G., Wu, B., Ward, M.G., Chong A.C., Mukherjee, S., Chen. S.*, and Hao, M.*, “Multifunctional In Vivo Imaging of Pancreatic Islets in Diabetes Development”, J. Cell Sci., 129, 2865. PMID: 27270669.

 

48. Feng, L., Cook, B., Tsai, S., Zhou, T., LaFlamme, B., Evans, T.*, Chen, S.*, “Discovery of a Small Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation”, Cell Reports, S2211-1247(16)30510-1. PMID: 27210748.

 

49. Simsek, S., Zhou, T., Robinson, C.L., Tsai, S., Crespo, M., Amin, S., Hon, J., Evans, T., Chen, S.*, “Modeling Cystic Fibrosis using PSC-derived Human Pancreatic Ductal Epithelial Cells”, STEM CELLS Translational Medicine, 5(5):572-9. PMID: 27034411.

 

50. Fattahi, F., Steinbeck, J.A., Kriks, S., Tchieu, J., Zimmer,B., Kishinevsky, S., Zeltner , N., Mica, Y., Nachef, W.E., Zhao, H., Stanchina, E. D.,  Gershon, M.D., Grikscheit, T.C., Chen, S., Studer, L., “Deriving Human ENS Lineages for Cell Therapy and Drug Discovery in Hirschsprung’s Disease”, Nature, 531(7592):105-9, PMID: 26863197.

 

51. Tsai, S.Y., Mass, K., Lu, J., Fishman, G.I. *, Chen, S.*, Evans, T. *, “Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling”, Stem Cell Reports, 4(6):1089-102, PMID: 26028533.

 

52. Kao, D., Lacko, L.A., Ding, B., Huang, C., Phung, K., Gu, G., Rafii, S., Stuhlmann, H., Chen,S.*, “Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling”, Stem Cell Reports, 4(2):181 (2015). PMID: 25601205.

 

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59. Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E.C., Ding, S., Schultz, P.G., “Reversine increases the plasticity of lineage-committed mammalian cells”, Proc. Natl. Acad. Sci., 104 (25), 10482 (2007), PMC1965539.

 

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