top of page

1. Yang, L., Han, Y., Zhang, T., Dong, X., Ge, J., Roy, A., Zhu, J., Lu, T., Vandana, J.J., de Silva, N., Robertson, C.C., Xiang, J., Pan, C., Sun, Y., Que, J., Evans, T., Liu, C., Wang, W., Naji, A., Parker, S.J., Schwartz, R.E.*,  Chen, S.*, “Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection”, Cell Stem Cell, 31: 196 (2024). PMID: 39232561.

 

2. Yang, L., Kim, T., Han, Y., Nair, M.S., Harschnitz, O., Zhu, J., Wang, P., Koo, S., Lacko, L.A., Chandar, V., Bram, Y., Zhang, T., Zhang, W., He, F., Pan, C., Wu, J., Huang, Y., Evans, T., van der Valk, P., Titulaer, M.J., Spoor, J.K.H., Furler, R.L., Bugiani, M., Berg, M., Schwartz, R.S.*, Ho, D.D.*, Studer, L.*, Chen, S.*, “SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence”, Cell Stem Cell, 31: 196 (2024).

 

3. Duan X., Zhang, T., Feng, L., de Silva N., Greenspun, B., Wang X., Moyer J., Martin, M.L., Chandwani, R., Elemento, O., Leach, S.D., Evans, T.*, Chen, S.*, Pan, F. *, “A Pancreatic Cancer Organoid Platform Identifies an Inhibitor Specific to Mutant KRAS”, Cell Stem Cell, 31: 71 (2024).

 

4. Chong, A.C., Vandana, J.J., Jeng, G., Li, G., Meng, Z., Duan X., Zhang, T., Qiu, Y., Duran-Struuck, R., Coker, K., Wang, W., Li, Y., Min, Z., Zuo, X., Silva, N., Chen, Z., Naji, A., Hao, M., Liu, C.,*, Chen, S.*, “Checkpoint Kinase 2 Controls Insulin Secretion and Glucose Homeostasis”, Nature Chemical Biology, In Press. PMID: 37945898.

 

5. Xue, D.#, Narisu, N.#, Taylor, D.L., Zhang. M,, Grenko, C., Taylor, H.J., Yan, T., Tang, X., Sinha, N., Zhu, J., Vandana, J.J., Chong, A.C., Lee, A., Mansell, E.C., Swift, A.J., Erdos, M.R., Zhong, A., Bonnycastle, L.L., Zhou, T., Chen, S.*, Collins, F.S.*, “Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells”, Cell Metabolism, 35, 1897 (2023). PMID: 37858332.

 

6. Hudaiberdiev. S.#, Taylor, L.D.#, Song, Wei, S.#, Narisu, N.,  Bhuiyan, R.M., Taylor, H.J., Tang, X., Yan, T.,  Swift, A.J., Bonnycastle, L.L., Diamante Consortium,  Chen, S.,  Stitzel, M.L., Erdos, M.R., Ovcharenko, I., Collins, F.S., “Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits”, Proc Natl Acad Sci U S A,120:e2206612120 (2023), PMID: 37603758.

 

7. Tan, L. #, Duan, X. #, Mutyala, P., Zhou, T., Amin, S., Zhang, T., Herbst, B., Askan, G., Itkin, T., Xiang., Z., Michelassi, F., Lieberman, M.D., Iacobuzio-Donahue, C.A., Leach, S.D., Evans, T., Chen, S.*, “A Targetable Pathway to Eliminate TRA-1-60+/TRA-1-81+ Chemoresistant Cancer Cells”, Journal of Molecular Cell Biology,  doi: 10.1093/jmcb/mjad039. PMID: 37327088

 

8. Yang, L.#, Han, Y.#, Zhou, T.#, Lacko L.A., Saeed, M., Tan, C., Danziger, R., Zhu, J., Zhao, Z., Cahir, C., Giani, A.M., Chai, Li, Y., Dong, X., Moroziewicz, D., The NYSCF Global Stem Cell Array® Team, Paull, D., Chen, Z., Zhong, A., Noggle, S.A., Rice, C.M., Qi, Q.,  Evans, T., Chen, S.*, “Isogenic human trophectoderm cells demonstrate the role of NDUFA4 and associated variants in ZIKV infection”, iScience, 26:107001(2023), PMID: 37534130.

 

9. Majd, H.,  Amin, S., Ghazizadeh, Z., Cesiulis, A., Arroyo, E., Lankford, K., Majd, A., Farahvashi, S., Chemel, A.K., Okoye, M., Scantlen, M.D., Tchieu, J., Calder, E.L., Rouzic, V.L., Shibata, B., Arab, A., Goodarzi, H., Pasternak, G., Kocsis, J.D., Chen, S., Studer, L., Fattahi, F.*, “Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy”, Cell Stem Cell, 30:632 (2023), PMID: 37146583.

 

10. Vandana, J.J., Manrique, C., Lacko L.A., Chen, S.*, “Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation”, Cell Stem Cell, 30:571, PMID: 37146581.

 

11. Rubio-Navarro, A.,  Gómez-Banoy, N., Stoll, L., Dündar, F., Mawla, A.M., Ma, L., Cortada, E.,  Zumbo, P., Li, A., Reiterer, M.,  Montoya-Oviedo, N., Homan, E.A., Imai, N., Gilani, A., Liu, C., Naji, A., Yang, B., Chong, A.C., Cohen, D.E.,  Chen, S., Cao, J., Pitt, G.S., Huising, M.O., Betel, D., Lo, J.C., “A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes”, Nature Cell Biology, 25:565 (2023), PMID: 36928765.

 

12. Tang, X., Xue, D., Zhang, T., Nilsson-Payant, B.E., Carrau L., Duan, X., Gordillo, M., Tan, A.Y., Xiang, J.,   Schwartz, R.E.*, tenOever, B.R.*, Evans, T.*, Chen, S.*, “A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection”, Nature Cell Biology, 25, 381 (2023), PMID: 36918693.

 

13. Han, Y., Tan, L., Zhou, T., Yang, L., Carrau, L., Lacko L.A., Saeed, M., Zhu, J., Zhao, Z., Nilsson-Payant, B.E., Lira Neto, F.T., Cahir, C., Giani, A.M., Chai, J., Li, Y., Dong, X., Moroziewicz, D., The NYSCF Global Stem Cell Array® Team, Paull, D., Zhang, T., Koo, S., Tan, C., Danziger1, R., Ba, Q., Feng, L., Chen, Z., Zhong, A., Wise, G.J., Xiang, J.Z., Wang, H., Schwartz, R.E., tenOever, B.R., Noggle, S.A., Rice, C.M., Qi, Q.,  Evans, T., Chen, S.*, “A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants”, Cell Stem Cell, 29, 1475 (2022), PMID: 36206731.

 

14. Han, Y., Yang, L., Lacko, L.A., Chen, S.*, “Human organoid models to study SARS-CoV-2 infection”, Nature Methods, 19, 418 (2022), PMID: 35396481.

 

15. Vandana, J.J., Lacko, L.A., Chen, S.*, “Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis”, Cell Stem Cell, 29, 873 (2022), PMID: 35659872.

 

16. Argueta, L.B., Lacko, L.A., Bram, Y., Tada, T., Carrau, L., Rendeiro, A.F., Zhang, T., Uhl, S., Lubor, B.C., Chandar, V., Gil, C., Zhang, W., Dodson, B.J., Bastiaans, J., Prabhu, M., Houghton, S., Redmond, D., Salvatore, C.M., Yang, Y.J., Elemento, O., Baergen, R.N., tenOever, B.R., Landau, N.R., Chen, S.* Schwartz, R.E.*, Stuhlamann, H.*, “Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy”, iScience, 25, 5 (2022), PMID: 35434541.

 

17. Yaron, T.M., Heaton, B.E., Levy, T.M., Johnson, J.L., Jordan, T.X., Cohen, B.M., Kerelsky, A., Liu, T., Liberatore, K.M., Bulaon, D.K., Nest, S.J.V., Koundouros, N., Kastenhuber, K.R., Mercadante, M.N., Shobana-Ganesh, K., He, L., Schwartz, R.E., Chen, S., Weinstein, H., Elemento, O., Piskounova, E., Nilsson-Payant., B.E., Lee, G., Trimarco, J.D., Burke, K.N., Hamele, C.E., Chaparian, R.P., Harding, A.T., Tata, A., Zhu, X., Tata, P.R., Smith, C.M., Possemato, A.P., Tkachev, S.L., Hornbeck, P.V., Heesom, K., Kavanagh-Williamson, M., Matthews, D.A., tenOever, B.R., Cantley, L.C., Blenis, J., Heaton, N.S., “Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication”, Science Signaling, 15, 757 (2022), PMID: 36282911.

 

18. Tee, S.S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R.M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E.R., Chen, S., Sigel, C., Low, S.W., Jarnagin, W.R., Thompson, C.B., Schietinger, A., Keshari, K.R., “Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging”, Science Advance, 8, 14 (2022), PMID: 35385296.

 

19. Ghazizadeh, Z., Zhu, J., Fattahi, F., Tang, A., Sun, X., Amin, S., Tsai, S.Y., Khalaj, M., Zhou, T., Samuel, R.M., Zhang, T., Ortega, F.A., Gordillo, M., Moroziewicz, D., NYSCF Global Stem Cell Array® Team, Paull, D., Noggle, S.A., Xiang, J.Z., Studer, L., Christini, D.J., Pitt, G.S., Evans, T., Chen, S.*, “A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for the derivation of human SAN-like cells”, iScience, 25, 104153 (2022), PMID: 35434558.

 

20. Lan, Y., Banks, K.M., Pan, H., Verma, N., Dixon, G.R., Zhou, T., Ding, B., Elemento, O., Chen, S., Huangfu, D., Evans, T., “Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation”, Cell Reports, 37, 110095, PMID: 34879277.

 

21. Han, Y., Zhu, J., Yang, L., Nilsson-Payant, B.E., Hurtado, R., Lacko, L.A., Sun, X., Gade, A.R., Higgins, C.A., Sisso, W.J., Dong, X., Wang, M., Chen, Z., Ho, D.D., Pitt, G.S., Schwartz, R.E.*, tenOever, B.R.*, Evans, T.*, Chen, S.*, “SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells”, “Circulation Research, 130, 963 (2022), PMID: 35255712.

 

22. Lan, Y., Banks, K.M., Pan, H., Verma, N., Dixon, G.R., Zhou, T., Ding, B., Elemento, O., Chen, S., Huangfu, D., Evans, T., “Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation”, Cell Reports. 37, 110095 (2021), PMID: 34879277.

 

23. Upadhya, S., Rehman, J. *, Malik, A.B. *, Chen, S.*, “Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection”, Physiology, (2021) PMID: 34698589.

 

24. Duan, X., Tang, X., Nair, M.S., Zhang, T., Qiu, Y., Zhang, W., Wang, P., Huang, Y., Xiang, J., Wang, H., Schwartz, R.E. *, Ho, D.D. *, Evans, T. *, Chen, S.*, “An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection”, Cell Reports, 37, 109920 (2021), PMID: 34731648.

 

25. Duan, X., Wang, H., Ho, D.D., Schwartz, R.E., Evans, T., Chen, S.*, “Comments on 'An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection'”, Journal of Molecular Cell Biology (2021), PMID: 34850919.

 

26. Duarte, R.R.R., Copertino, D.C., Jr., Iñiguez, L.P., Marston, J.L., Bram, Y., Han, Y., Schwartz, R.E., Chen, S., Nixon, D.F., Powell, T.R., “Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry”, Molecular Medicine, 27,105, (2021), PMID: 34503440.

 

27. Tang, X., Uhl, S., Zhang, T., Xue, D., Li, B., Vandana, J.J., Acklin, J.A., Bonnycastle, L.L., Narisu, N., Erdos, M.R., Bram, Y., Lacko, L.A., Min, Z., Lim, J.K.,  Borczuk, A., Xiang, J., Naji, A., Collins, F.S., Evans, T., Liu, C.,*, tenOever, B.R. *, Schwartz, R.E.,*, Chen, S.*, “SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation”, Cell Metabolism, 21, S1550 (2021), PMID: 34081913.

 

28. Yang., L, Han, Y., Jaffré, F., Nilsson-Payant, B.N., Bram, Y., Wang, P., Zhu, J., Zhang,T., Redmond, D., Houghton, S., Uhl, S., Borczuk, A., Huang, Y., Richardson, C., Chandar, V., Acklin, J.A., Lim, J.K., Xiang, J., Ho, D.H. *, tenOever, B.R. *, Schwartz, R.E.,*, Evans, T.,*, Chen, S.*, “An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts”, Circulation Research, 129, 33 (2021), PMID:33853355.

 

29. Yang., L, Nilsson-Payant, B.N., Han, Y., Jaffré, F., Zhu, J., Wang, P., Zhang,T., Redmond, D., Houghton, S., Møller, R., Carrau, L., Horiuchi, S., Goff, M., Lim, J.K., Bram, Y., Richardson, C., Chandar, V., Borczuk, A., Huang, Y., Xiang, J., Ho, D.H. *, Schwartz, R.E.,*, tenOever, B.R. *, Evans, T.,*, Chen, S.*, “Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2”, Stem Cell Reports, 16, 2274 (2021), PMID: 34403650.

 

30. Han, Y., Duan, X., Yang, L., Nilsson-Payant, B.E., Wang, P., Duan, F., Tang, X., Yaron, T.M., Zhang, T., Uhl, S., Bram Y., Richardson, C., Zhu, J., Zhao, Z., Redmond. D., Houghton, S., Nguyen, D.T., Xu, D., Wang, X., Jessurun, J., Borczuk, A., Huang, Y., Johnson, J.L., Liu, Y., Xiang, J., Wang, H. *, Cantley, L.C.*, tenOever, B.R.*, Ho, D.D.*, Pan, F*, Evans, T*, Chen, H.J.*, Schwartz, R.E.*, Chen, S.*, “Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids”, Nature, 589, 270 (2020), PMID: 33116299.

 

31. Yang, L., Han, Y., Nilsson-Payant, B.E., Gupta, V., Wang, P., Duan, X., Tang, X., Zhao, Z., Jaffré, F., Zhang, Tuo., Kim T.W., Harschnitz, O., Redmond. D., Houghton, S., Liu, C., Naji, A., Ciceri, G., Guttikonda, S., Bram, Y., Nguyen, D.T., Gioffi, M., Chandar, V., Hoagland, D.A., Huang, Y., Xiang, J., Wang, H., Lyden, D., Borczuk, A., Chen, H.J., Studer, L., Pan, F.C. *, Ho, D.D. *, tenOever, B.R. *, Evans, T. *, Schwartz, R.E. *, Chen, S.*, “A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids”, Cell Stem Cell, 27, 125 (2020), PMID: 32579880.

 

32. Cederquist, G.Y., Tchieu, J., Callahan, S.J., Ramnarine, K., Ryan, S., Zhang, C., Rittenhouse, C., Zeltner, N., Chung, S.Y., Zhou, T., Chen, S., Betel, D., White, R.M., Tomishima, M., Studer, L., “A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes”, Cell Stem Cell,  27, 35 (2019), PMID: 32619517.

 

33. Cook, B., Walker, N., Zhang, Q., Chen, S.*, Evans T*, “The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3-beta signaling”, Journal of Biological Chemistry, 296, 1006962021, (2021), PMID: 33895139.

 

34. Li, Q.V., Dixon, G., Verma, N., Rosen, B.P., Gordillo, M., Luo, R., Xu, C., Wang, Q., Soh, C., Yang, D., Crespo, M., Shukla, A., Xiang, Q., Dündar, F., Zumbo, P., Witkin, M., Koche, R., Betel, D., Chen, S., Massagué, J., Garippa, R., Evans, T., Beer, M.A., Huangfu, D., “Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation”, Nature Genetics, 51, 999 (2019), PMID: 31110351.

 

35. Vandana, J.J., Lacko, L.A., Chen, S. *, “High Throughput Phenotypic Screens in Stem Cell Biology”, Cell Chemical Biology, 28(3):257-70, PMID: 33651977.

 

36. Giani, A.M., Chen, S. *, “Human Pluripotent Stem Cell-based Organoids and Cell Platforms for Modelling SARS-CoV-2 Infection and Drug Discovery”, Stem Cell Reseserch, 53:102207, PMID: 33677394.

 

37. Sleiman, Y., Souidi, M., Kumar, R., Yang, E., Jaffré, F., Zhou, T., Bernardin, A., Reiken, S., Cazorla, O., Kajava, A.V., Moreau, A., Pasquié, J.L., Marks, A.R., Lerman, B.B., Chen, S., Cheung, J.W., Evans, T., Lacampagne, A., Meli, A.C., “Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes”, EBioMedicine., 60,103024, (2020), PMID: 32980690.

 

38. Tsai, S.Y., Ghazizadeh, Z., Wang, H.J., Amin, S., Ortega, F.A., Badieyan, Z.S., Hsu, Z.T., Gordillo, M., Kumar, R., Christini, D.J., Evans, T. *, Chen, S.*, “A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity”, Cardiovascular Research, 116, 658 (2020), PMID: 31173076.

 

39. Pan, F.C. *, Evans, T. *, Chen, S.*, “Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids.” Journal of Molecular Cell Biology, 12, 580 (2020). PMID: 32652003.

 

40. Zhang, M., Vandana, J.J., Lacko, L.A., Chen, S. *, “Modeling cancer progression using human pluripotent stem cell-derived cells and organoids”, Stem Cell Research, 49:102063, (2020), PMID: 33137568.

 

41. Lacko, L.A., Chen, S. *, “Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics”, Journal of Molecular Cell Biology, 12(8):666-7, (2020), PMID: 31638141.

 

42. Tan, L., Lacko, L.A., Zhou, T., Tomoiaga, D., Hurtado, R., Zhang, T., Sevilla, A., Mason, C., Noggle, S., Evans, T., Stuhlmann, H.*, Schwartz, R.E.*, Chen, S.*, “Pre- and Peri-implantation Zika Virus Infection Impairs Fetal Development by Targeting Trophectoderm Cells”, Nature Communications, 10, 4155 (2019), PMID: 31519912.

 

43. Cook, B., Rafiq, R., El-Debs, M., Chiaravalli, J., Glickman, J.F., , and Evans, T.,*, “”, 31031140.

 

44. Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., Stanley, V., Guemez-Gamboa, A., Evans, T., Chen. S., Tan, L., Molina, H., Sheets, N., Shiryaev S.A., Terskikh A.V., Gladfelter, A.S., Shresta, S., Xu, Z., Gleeson, J.G., “Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors”, Neuron, 101:1, (2019), PMID: 30713029

 

45. Zhou, T., Kim, T.W., Chong, C.N., Tan, L., Amin, S., Mukherjee, S., Ghazizadeh, Z., Zeng, H., Guo, M., Crespo, M., Zhang, T., Kenyon, R., Robinson, C.L., Apostolou, E., Wang, H., Xiang, J.Z., Evans, T., Studer, L., Chen. S.*, “A Pluripotent Stem Cell-based Platform to Discover Gene-Environment Interactions that Impact Human Pancreatic β -Cell and Dopamine Neuron Survival”, Nature Communications, 9:4815, (2018), PMID: 30446643.

 

46. Amin, S., Cook, B., Zhou, T., Ghazizadeh, Z., Lis, R., Zhang, T., Khalaj, M., Crespo, M., Perera, M., Xiang, J.Z., Zhu, Z., Tomishima, T., Liu, C., Naji, A., Evans, T., Huangfu, D. *, Chen. S.*, “Discovery of a Drug Candidate for GLIS3-Associated Diabetes”, Nature Communications, 9, 2681, (2018), PMID: 29992946.

 

47. Robinson, C.L., Chong, A.C., Ashbrook, A.W., Jeng, G., Jin, J., Chen, H., Tang, E.I., Martin, L.A., Kim, R.S., Kenyon, R.M., Do, E., Luna, J.M., Saeed, M., Zeltser, L., Ralph, H., Dudley, V.L., Goldstein, M., Rice, C.M., Cheng, C.Y.*, Seandel, M.*, Chen. S.*, “Male Germ Cells Support Long-Term Propagation of Zika Virus”, Nature Communications, 9:2090, (2018), PMID: 29844387.

 

48. Mukherjee, S., Zhang, T., Lacko, L.A., Xiang, J.Z., Bulter, J.M., Derivation and characterization of a UCP1 reporter human ES cell line”, Stem Cell Research, 30:12-21. 2018. PMID: 29777802. 

 

49. Crespo, M., Vilar, E., Tsai, S., Chang, K., Amin, S., Srinivasan, T., Zhang, T., Pipalia, N.H., Chen, H.J., Witherspoon, M., Gordillo, M., Xiang, J.Z., Maxfield, F.R., Lipkin, S., Evans, T.*, Chen. S.*, “Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing”, Nature Medicine, 23(7):878-884. PMID: 28628110. (Cover story, highlighted by Nat Rev Mol Cell Bio)

 

50. Zhou, T., Tan, L., Cederquist, Y. C., Fan, Y., Hartley, B.J., Mukherjee, S., Tomishima, M., Brennand, K.J., Zhang. Q., Schwartz, R.E., Evans T., Studer, L.*, and Chen, S.*, “High Content Screening in hESC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain”, Cell Stem Cell, 21(2):274-283.e5, PMID: 28736217.

 

51. Shi, Z.D., Lee, K., Yang, D., Amin, S., Verma, N., Li, Q.V., Zhu, Z., Soh, C.L., Kumar, R., Evans, T., Chen. S.*, Huangfu, D.*, “hPSC modeling of GATA6 haploinsufficiency in human pancreatic development”, Cell Stem Cell, 20(5):675-688 (2017), PMID: 2819660.

 

52. Guo, M., Zhang, T., Dong, X., Xiang, J.Z., Lei, M., Evans, T., Graumann, J., Chen. S.*, “Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E”, Cell Reports, 19(8):1512 (2017), PMID: 28538172.

 

53. Ghazizadeh, Z., Kao, D., Amin, S., Cook, B., Rao, S., Zhang, T., Xiang, J.Z., Kenyon, R., Kaymakcalan, O., Liu, C., Evans T., Chen. S.*, “ROCKII Inhibition Promotes the Maturation of Human Pancreatic Beta-like Cells”, Nature Communications, 8 (1): 298 (2017), PMID: 28824164.

 

54. Tchieu, J., Zimmer, B., Fattahi, F., Amin, S., Zeltner, N., Chen, S., Studer, L., “A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages”, Cell Stem Cell, 21(3):399-410.e7, (2017), PMID: 28886367.

 

55. Zeng, H., Guo, M., Zhou, T., Tan, Lei., Chong, C., Zhang, T., Dong, X., Xiang, J. X., Yu, A.S., Yue, L., Qi, Q, Evans, T., Graumann, J., Chen. S.*, “An Isogenic Human ESC Platform for Functional Evaluation of GWAS Identified Diabetes Genes and Drug Discovery”, Cell Stem Cell, 19: 324 (2016), PMID: 27524441.

 

56. Chen, H.J., Wei, Z., Sun, J., Bhattacharya, A., Savage, D.J., Serda, R., Mackeyev, Y., Curley, S.A., Bu, P., Wang, L., Chen, S., Cohen-Gould, L., Huang, E., Shen, X., Lipkin, S.M., Copeland, N.G., Jenkins, N.A., Shuler, L. “A recellularized human colon model identifies cancer driver genes.” Nature Biotechnology. (8):845-51, PMID: 27398792.

 

57. Tsai, S., Chen, S., Evans T., “Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling”, Current Protocols in Stem Cell Biology, 40:1F.16.1, PMID: 28152183

 

58. Li, G., Wu, B., Ward, M.G., Chong A.C., Mukherjee, S., Chen. S.*, and Hao, M.*, “Multifunctional In Vivo Imaging of Pancreatic Islets in Diabetes Development”, J. Cell Science, 129, 2865. PMID: 27270669.

 

59. Feng, L., Cook, B., Tsai, S., Zhou, T., LaFlamme, B., Evans, T.*, Chen, S.*, “Discovery of a Small Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation”, Cell Reports, S2211-1247(16)30510-1. PMID: 27210748.

 

60. Simsek, S., Zhou, T., Robinson, C.L., Tsai, S., Crespo, M., Amin, S., Hon, J., Evans, T., Chen, S.*, “Modeling Cystic Fibrosis using PSC-derived Human Pancreatic Ductal Epithelial Cells”, STEM CELLS Translational Medicine, 5(5):572-9. PMID: 27034411.

 

61. Fattahi, F., Steinbeck, J.A., Kriks, S., Tchieu, J., Zimmer,B., Kishinevsky, S., Zeltner , N., Mica, Y., Nachef, W.E., Zhao, H., Stanchina, E. D.,  Gershon, M.D., Grikscheit, T.C., Chen, S., Studer, L., “Deriving Human ENS Lineages for Cell Therapy and Drug Discovery in Hirschsprung’s Disease”, Nature, 531(7592):105-9, PMID: 26863197.

 

62. Tsai, S.Y., Mass, K., Lu, J., Fishman, G.I. *, Chen, S.*, Evans, T. *, “Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling”, Stem Cell Reports, 4(6):1089-102, PMID: 26028533.

 

63. Kao, D., Lacko, L.A., Ding, B., Huang, C., Phung, K., Gu, G., Rafii, S., Stuhlmann, H., Chen,S.*, “Endothelial Cells Control Pancreatic Cell Fate at Defined Stages through EGFL7 Signaling”, Stem Cell Reports, 4(2):181 (2015). PMID: 25601205.

 

64. Song, W., An, D., Kao, D., Lu, Y., Dai, G., Chen, S., Ma, M., "Nanofibrous Microposts and Microwells of Controlled Shapes and Their Hybridization with Hydrogels for Cell Encapsulation", ACS Applied Materials & Interfaces, 6 (10), 7038 (2014). PMID:24806031

 

65. Ye, J., Chen, S., Maniatis, T., “Cardiac glycosides are potent inhibitors of interferon-β gene expression.” Nature Chemical Biology, 7 (1), 25 (2011), PMC3076628.

 

66. Chen, S., Borowiak, M., Fox, J.L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L.F., Schreiber, S.L., Rubin, L.L., Melton, D.A., “A small molecule that directs differentiation of human ESCs into the pancreatic lineage.” Nature Chemical Biology, 5 (4), 258 (2009).

 

67. Maehr, R., Chen, S., Snitow, M., Ludwig, T., Yagasaki, L., Goland, R., Leibel, R.L., Melton, D.A., “Generation of pluripotent stem cells from patients with type 1 diabetes.”, Proc. Natl. Acad. Sci., 106 (37), 15768 (2009), PMC2735559.

 

68. Borowiak, M., Maehr, R., Chen, S., Chen, A.E., Tang, W., Fox, J.L., Schreiber, S.L., Melton, D.A., “Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.” Cell Stem Cell, 4 (4), 348 (2009).

 

69. Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D.A., “Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2”, Nature Biotechnology, 26 (11), 1269 (2008).

 

70. Chen, S., Takanashi, S., Zhang, Q., Xiong, W., Zhu, S., Peters, E.C., Ding, S., Schultz, P.G., “Reversine increases the plasticity of lineage-committed mammalian cells”, Proc. Natl. Acad. Sci., 104 (25), 10482 (2007), PMC1965539.

 

71. Qyang, Y., Martin-Puig, S., Chiravuri, M., Chen, S., Xu, H., Bu, L., Jiang, X., Lin, L., Granger, A., Moretti,  A.,Caron, L., Wu, X., Clarke, J., Taketo, M.M., Laugwitz, K., Moon, R.T., Gruber, G., Evans, S.M., Ding, S., Chien, K., “The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway”, Cell Stem Cell, 1 , 165 (2007). PMID: 18371348.

 

72. Liu, W., Brock, A., Chen, S., Chen, S., Schultz, P.G., “Genetic incorporation of unnatural amino acids into proteins in mammalian cells”, Nature Methods, 4 (3), 205 (2007). PMID: 17322890.

 

73. Chen, S., Do, J., Zhang, Q., Yao, S., Yan, F., Peters, E.C., Scholer, H.R., Schultz, P.G. Ding, S., “Self-renewal of embryonic stem cells by a small molecule”, Proc. Natl. Acad. Sci., 103 (46), 17266 (2006). PMID: 17088537

 

74. Yao, S., Chen, S., Clark, J., Hao, E., Beattie, G., Hayek, A., Schultz, P.G., Ding, S., “Long term selfrenewal and directed differentiation of human embryonic stem cells in chemically defined conditions”, Proc. Natl. Acad. Sci.,103 (18), 6907 (2006), PMC1458992.

 

75. Chen, S., Hilcove, S. and Ding, S., “Exploring stem cell biology with small molecules”, Molecular Biosystems, 2 (1), 18 (2006). PMID: 16880919.

 

76. Chen, S., Ding, S., “GSK-3 and stem cells”, Glycogen synthase kinase-3 (GSK-3) and its inhibitors. New Jersey:John Wiley & Sons, 155 (2006).

 

77. Chen, S., Zhang, Q., Wu, X., Schultz, P.G., Ding, S., “Dedifferentiation of lineage-committed cells by a small molecule”, J. Am. Chem. Soc., 126 (2), 410 (2004). PMID: 14719906.

 

78. Chen, S., Li, Y., Zhao, Y., “The Study of Phosphoramidite as O-phosphitylation Agent and Its Reactivity”, Phosphorus, Sulfur and Silicon, 164: 277 (2000).

 

79. Chen, Z., Chen, S., Chen, Y., Li, Y., Chen, J., Zhao, Y., “Negative-ion electrospray ionization tandem mass spectrometry of N-phosphoryl amino acids and dipeptides”, Rapid Comm. In Mass Spect., 16 (8), 790, (2002). PMID: 11921264.

bottom of page